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Publications

Recent publications

2017

1. SERAFIM, RICARDO A. M. ; DE OLIVEIRA, TIAGO F. ; LOUREIRO, ANA P. M. ; KROGH, RENATA ; Andricopulo, Adriano D. ; DIAS, LUIZ C. ; Ferreira, Elizabeth I. . Molecular modeling and structure-activity relationships studies of bioisoster hybrids of N-acylhydrazone and furoxan groups on cruzain. MEDICINAL CHEMISTRY RESEARCH, v. 26, p. 760-769, 2017.

 

2. MONTEIRO, LIS MARIE ; LÖBENBERG, RAIMAR ; Ferreira, Elizabeth Igne ; COTRIM, PAULO CESAR ; KANASHIRO, EDITE ; ROCHA, MUSSYA ; Chin, Chung Man ; BOU-CHACRA, NADIA . Targeting Leishmania amazonensis amastigotes through macrophage internalisation of a hydroxymethylnitrofurazone nanostructured polymeric system. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. xx, p. xx-xx, 2017.

 

3. SERAFIM, R. A. M. ; PERNICHELLI, F. G. ; FERREIRA, E. I . The latest advances in the discovery of nitric oxide hybrid drug compounds. Expert Opinion on Drug Discovery, v. 12, p. 941-953, 2017.

 

4.

SANTOS, S. S. ; GONZAGA, R. V. ; SILVA, J. V. ; SAVINO, D. F. ; PRIETO, D. ; SHIKAY, J. M. ; SILVA, R. S. ; PAULO, L. H. A. ; FERREIRA, E. I ; GIAROLLA, J. . Peptide dendrimers: Drug/dene delivery and other approaches. CANADIAN JOURNAL OF CHEMISTRY, v. 95, p. 907-916, 2017.

2016

5. DA SILVA SANTOS, SORAYA ; IGNE FERREIRA, ELIZABETH ; Giarolla, Jeanine . Dendrimer Prodrugs. Molecules (Basel. Online), v. 21, p. 686-707, 2016.

6. SILVA, FREDSON T. ; FRANCO, CAIO H. ; FAVARO, DENIZE C. ; FREITAS-JUNIOR, LUCIO H. ; MORAES, CAROLINA B. ; Ferreira, Elizabeth I. . Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues. European Journal of Medicinal Chemistry, v. 121, p. 553-560, 2016.

 

7. SEGRETTI, NATANAEL D. ; SERAFIM, RICARDO A.M. ; SEGRETTI, MARIANA C.F. ; MIYATA, MARCELO ; COELHO, FERNANDO R. ; AUGUSTO, OHARA ; Ferreira, Elizabeth I. . New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors. Bioorganic & Medicinal Chemistry Letters (Print), v. 26, p. 3988-3993, 2016.

2015

8. Giarolla, Jeanine ; FERREIRA, E. I . Drug Design for Neglected Disease in Brazil. Mini-Reviews in Medical Chemistry, v. 15, p. 220-242, 2015.

9. DA SILVA SANTOS, SORAYA ; Giarolla, Jeanine ; Pasqualoto, Kerly F.M. ; Ferreira, Elizabeth I. . In silico study to analyse the disassembly of quercetin-targeted dendrimers potentially leishmanicide. Molecular Simulation (Print), v. 41, p. 1-14, 2015.

10.

TAVARES, M. T. ; PRIMI, M. C. ; POLLI, M. C. ; FERREIRA, E. I. ; PARISE FILHO, R. . 'DRUG-RECEPTOR INTERACTIONS: IN SILICO APPROACHES APPLIED TO EXPERIMENTAL CLASS REGARDING THE EVOLUTION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS'. Química Nova (Impresso), v. 38, p. 117-1124, 2015.

 

11.

PRIMI, MARINA ; SEGRETTI, NATANAEL ; Ferreira, Elizabeth . Medicinal Chemistry of New Compounds to Treat Tuberculosis. Current Clinical Pharmacology, v. 10, p. 139-159, 2015.

 

12. MONTEIRO, L. M. ; TAVARES, G. D. ; FERREIRA, E. I. ; CONSIGLIERI, V. O. ; BOU-CHACRA, N. A. ; LOEBENBERG, R. . Reverse Phase High-Performance Liquid Chromatography for quantification of hydroxymethylnitrofurazone in polymeric nanoparticles. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. 51, p. 561-567, 2015.

2014

13. SERAFIM, R. A. M. ; GONCALVES, J. E. ; SOUZA, F. P. ; LOUREIRO, A. P. M. ; STORPIRTIS, S. ; KROGH, R. ; Ancricopulo, A. D. ; DIAS, L. C. ; FERREIRA, E. I. . Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity. European Journal of Medicinal Chemistry, v. 82, p. 418-425, 2014.

2013

14.​SANTOS, S. S. ; GIAROLLA, J. ; PASQUALOTO, K. F. M. ; Ferreira, Elizabeth Igne ; FERREIRA, E. I . Molecular modelling as a tool for studying the disassembly of potentially leishmanicide-targeted dendrimer. Molecular Simulation (Print), p. 1-8, 2013.

 

15.SERAFIM, E. O. P. ; SILVA, A. T. D. A. ; MORENO, A. D. H. ; VIZIOLI, E. D. O. ; FERREIRA, E. I. ; PECCININI, R. G. ; RIBEIRO, M. L. ; CHUNG, M. C. . Pharmacokinetic of NFOH, a New Promising Prodrug for Chagas' Disease Treatment. Antimicrobial Agents and Chemotherapy (Print), v. 57, p. 6106-6109, 2013.

 

16.Giarolla, Jeanine ; Pasqualoto, Kerly Fernanda Mesquita ; Ferreira, Elizabeth I. . Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide. Molecular Diversity, v. 17, p. 711-720, 2013.

Citações:4|5

 

17.BRITO, CHARLES DE LIMA ; TROSSINI, GUSTAVO HENRIQUE GOULART ; Ferreira, Elizabeth Igne ; LA-SCALEA, MAURO AQUILES . Nitrofurazone and its Nitroheterocyclic Analogues: a Study of the Electrochemical Behavior in Aqueous Medium. Journal of the Brazilian Chemical Society (Impresso), v. 24, p. 1964-1973, 2013.

 

18.BUENO, RENATA ; BRAGA, RODOLPHO ; SEGRETTI, NATANAEL ; Ferreira, Elizabeth ; Trossini, Gustavo ; ANDRADE, CAROLINA . New Tuberculostatic Agents Targeting Nucleic Acid Biosynthesis: Drug Design using QSAR Approaches. Current Pharmaceutical Design (Print), v. 20, p. 4474-4485, 2013.

2012

19.Turra, Kely Medeiros ; Pasqualoto, Kerly Fernanda Mesquita ; Ferreira, Elizabeth Igne ; Rando, Daniela Gonçales . Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G2. Journal of Molecular Modeling, v. 18, p. 1867-1875, 2012.

 

20.Giarolla, Jeanine ; Pasqualoto, Kerly F. M. ; Rando, Daniela G. ; Zaim, Márcio H. ; Ferreira, Elizabeth I. . Molecular modeling study on the disassembly of dendrimers designed as potential antichagasic and antileishmanial prodrugs. Journal of Molecular Modeling, v. 18, p. 2257-2269, 2012.

 

21.SERAFIM, R. A. M. ; PRIMI, M.C. ; TROSSINI, G. H. G. ; FERREIRA, E. I . Nitric Oxide: State of the Art in Drug Design. Current Medicinal Chemistry, v. 19, p. 386-405, 2012.

 

22.FERREIRA, E. I. Drug Design for Chagas'Disease: Advances and Challenges. Revista Virtual de Química, v. 4, p. 225-246, 2012.

2011

 

23.dos Santos, Kátia S.C.R. ; Matos, Jivaldo R. ; Ferreira, Elizabeth I. . Synthesis and Chemical Characterization of a Polymeric Prodrug for Prolonged Release of Nitrofurazone. Macromolecular Symposia, v. 299-300, p. 113-123, 2011.

 

24.Fernandes, João Paulo S. ; Pasqualoto, Kerly Fernanda M. ; Ferreira, Elizabeth I. ; Brandt, Carlos A. . Molecular modeling and QSAR studies of a set of indole and benzimidazole derivatives as H4 receptor antagonists. Journal of Molecular Modeling, v. 17, p. 921-928, 2011.

2010

 

25.Fernandes, João P. S. ; Pasqualoto, Kerly F. M. ; Felli, Veni M. A. ; Ferreira, Elizabeth I. ; Brandt, Carlos A. . QSAR Modeling of a Set of Pyrazinoate Esters as Antituberculosis Prodrugs. Archiv der Pharmazie (Weinheim), v. 343, p. 91-97, 2010.

 

26.RANDO, D. G. ; GIAROLLA, J. ; PASQUALOTO, K. F. M. ; FERREIRA, E. I. . Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential antileishmanial new agents. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. 46, p. 311-321, 2010.

 

27.PARISE FILHO, R. ; POLLI, M. C. ; BARBERATO FILHO, S ; GARCIA, M. ; Ferreira, Elizabeth Igne . Prodrugs available in the Brazilian pharmaceutic market and their corresponding bioactivation pathways. Brazilian Journal of Pharmaceutical Sciences (Impresso), v. 46, p. 393-420, 2010.

 

28.Andrade, Carolina Horta ; Pasqualoto, Kerly F. M. ; Ferreira, Elizabeth I. ; Hopfinger, Anton J. . 3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents. Journal of Computer-Aided Molecular Design, v. 24, p. 157-172, 2010.

29. TROSSINI, G. H. G. ; GIAROLLA, J. ; REZENDE, L. ; AMARAL, A. T. ; ZAIM, M. H. ; BRUNS, R. E. ; FERREIRA, E. I . SYNTHESIS OPTIMIZATION OF HYDROXYMETHYLNITROFURAZONE, AN ANTICHAGASIC CANDIDATE, USING 32 FACTORIAL DESIGN. Letters in Organic Chemistry, v. 7, p. 191-195, 2010.

 

30.Trossini, Gustavo H. G. ; Malvezzi, Alberto ; T.-do Amaral, Antonia ; Rangel-Yagui, Carlota Oliveira ; Izidoro, Mario A. ; Cezari, Maria Helena S. ; Juliano, Luiz ; Chin, Chung Man ; Menezes, Carla M. S. ; Ferreira, Elizabeth Igne ; Ferreira, Elizabeth Igne . Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 25, p. 62-67, 2010.

 

31.PAULA, F. R. ; TROSSINI, G. H. G. ; FERREIRA, E. I ; SERRANO, S. H. P. ; MENEZES, C. M. S. ; TAVARES, L. C. . Theoretical and voltammetric studies of 5-nitro-heterocyclic derivatives with potential trypanocidal activities. Journal of the Brazilian Chemical Society (Online), v. 21, p. 740-749, 2010.

 

32.Andrade, Carolina H. ; Pasqualoto, Kerly F. M. ; Ferreira, Elizabeth I. ; Hopfinger, Anton J. . 4D-QSAR: Perspectives in Drug Design. Molecules (Basel), v. 15, p. 3281-3294, 2010.

 

33.ANDRADE, C. H. ; TROSSINI, G. H. G. ; FERREIRA, E. I. . MODELAGEM MOLECULAR NO ENSINO DE QUÍMICA FARMACÊUTICA. Revista Eletrônica de Farmácia, v. 7, p. 1-23, 2010.

 

34.TROSSINI, G. H. G. ; CHUNG, M. C. ; MENEZES, C. M. S. ; FERREIRA, E. I. . Molecular Modeling Suggests Cruzain Specificity for Peptide Primaquine Prodrugs. Letters in Drug Design & Discovery, v. 7, p. 528-533, 2010.

 

35.Quincoces Suarez, José Agustín ; Rando, Daniela Gonçales ; Santos, Reginaldo Pereira ; Gonçalves, Carolina Passarelli ; Ferreira, Elizabeth ; de Carvalho, João Ernesto ; Kohn, Luciana ; Maria, Durvanei Augusto ; Faião-Flores, Fernanda ; Michalik, Dirk . New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives. Bioorganic & Medicinal Chemistry (Print), v. 18, p. 6275-6281, 2010.

36.SCOTTI, L. ; FERREIRA, E. I. ; SOBRAL, M. ; SCOTTI, M. T. . Chemometric Studies on Natural Products as Potential Inhibitors of the NADH Oxidase from Trypanosoma cruzi Using. Molecules (Basel. Online), v. 15, p. 7363-7377, 2010.

2009

 

37.Trossini, Gustavo H.G. ; Guido, Rafael V.C. ; Oliva, Glaucius ; Ferreira, Elizabeth I. ; Andricopulo, Adriano D. . Quantitative structure activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: Molecular modeling, CoMFA and CoMSIA studies. Journal of Molecular Graphics & Modelling, p. 3-11, 2009.

 

38.Andrade, Carolina H. ; Pasqualoto, Kerly F. M. ; Ferreira, Elizabeth I. ; Hopfinger, Anton J. . Rational Design and 3D-Pharmacophore Mapping of 5?-Thiourea-Substituted ?-Thymidine Analogues as Mycobacterial TMPK Inhibitors. Journal of Chemical Information and Modeling, v. 49, p. 1070-1078, 2009.

 

39.Giarolla, Jeanine ; Rando, Daniela G. ; Pasqualoto, Kerly F.M. ; Zaim, Márcio H. ; Ferreira, Elizabeth I. . Molecular modeling as a promising tool to study dendrimer prodrugs delivery. Journal of Molecular Structure. Theochem (Print), v. 939, p. 133-138, 2009.

 

40.La-Scalea, M. A. ; TROSSINI, G. H. G. ; MENEZES, C. M. S. ; CHUNG, M. C. ; Ferreira, E. I. ; Ferreira, Elizabeth Igne . Electrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug:?NFOH. Journal of the Electrochemical Society, v. 156, p. F93-F97, 2009.

 

41.SCOTTI, L. ; SCOTTI, M. T. ; PASQUALOTO, K. F. M. ; BOLZANI, V. S. ; FERREIRA, E. I. . Molecular physicochemical parameters predicting antioxidant activity of Brazilian natural products. Revista Brasileira de Farmacognosia (Impresso), v. 19, p. 908-913, 2009.

2008

42.BRAGA, M. E. M. ; PATO, M. T. V. ; SILVA, H. S. R. C. ; FERREIRA, E. I ; GIL, M. H. ; DUARTE, C. M. M. ; SOUSA, H. C. . Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives. The Journal of Supercritical Fluids, v. 44, p. 245-257, 2008.

Citações:57|58

 

43.SILVA, M. ; MENEZES, C. M. S. ; FERREIRA, E. I ; LEITE, C. Q. F. ; SATO, D. N. ; CORREIA C C ; PIMENTA C C ; BOTELHO, K. C. A. . Topliss method in the optimization of salicylic acid derivatives as potential antimycobacterial agents. Chemical Biology and Drug Design, v. 71, p. 167-172, 2008.

 

44.BLAU, L. ; MENEGON, R. F. ; FERREIRA, E. I ; FERREIRA, A. G. ; BOFFO, E. F. ; TAVARES, L. A. ; HELENO, V. C. ; CHUNG, M. C. . Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches. Molecules Online, v. 13, p. 841-854, 2008.

 

45.CHUNG, M. C. ; FERREIRA, E. I ; SANTOS, J. L. ; GIAROLLA, J. ; RANDO, D. G. ; ALMEIDA, A. E. ; BOSQUESI, P. L. ; MENEGON, R. F. ; BLAU, L. . Prodrugs for the treatment of neglected diseases. Molecules Online, v. 13, p. 616-677, 2008.

 

46.Grillo, R. ; Melo, N. F. S. ; Moraes, C. M. ; de Lima, R. ; MENEZES, C. M. S. ; FERREIRA, E. I ; Rosa, A. H. ; FRACETO, L. F. . Study of the interaction between hydroxymethylhitrofurazone and 2-hydroxypropyl-beta-cyclodextrin. Journal of Pharmaceutical and Biomedical Analysis, v. 46, p. 295-302, 2008.

 

47.Grillo, R. ; Melo, N. F. S. ; FRACETO, L. F. ; BRASILEIRA, C. P. R. F. ; BRITO, C. L. ; TROSSINI, G. H. G. ; MENEZES, C. M. S. ; FERREIRA, E. I ; Moraes, C. M. . Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina. Química Nova, v. 31, p. 290-295, 2008.

 

48.RANDO, D. G. ; AVERY, M ; TEKWANI, B ; KHAN, S ; FERREIRA, E. I. . Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides. Bioorganic & Medicinal Chemistry, v. 16, p. 6724-6731, 2008.

 

49.ANDRADE, C. H. ; SALUM, L. B. ; Castilho, M. S. ; PASQUALOTO, K. F. M. ; FERREIRA, E. I. ; Andricopulo, A. D. . Fragment-based and classical quantitative structure activity relationships for a series of hydrazides as antituberculosis agents. Molecular Diversity, v. 12, p. 47-59, 2008.

 

50.ANDRADE, C. H. ; PASQUALOTO, K. F. M. ; ZAIM, M. H. ; FERREIRA, E. I. . Abordagem racional no planejamento de novos tuberculostáticos: inibidores da InhA, enoil-ACP redutase do M. tuberculosis. RBCF. Revista Brasileira de Ciências Farmacêuticas, v. 43, p. 167-179, 2008.

51.ANDRADE, C. H. ; SALUM, L. B. ; PASQUALOTO, K. F. M. ; FERREIRA, E. I ; Andricopulo, Adriano D. . Three-dimensional quantitative structure-activity relationships for a large series of potent antitubercular agents. Letters in Drug Design & Discovery, v. 5, p. 377-387, 2008.

 

52.Guido, Rafael V. C. ; Trossini, Gustavo H. G. ; Castilho, Marcelo S. ; Oliva, Glaucius ; Ferreira, Elizabeth I. ; Andricopulo, Adriano D. . Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from. Journal of Enzyme Inhibition and Medicinal Chemistry (Online), v. 23, p. 964-973, 2008.